Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance
نویسندگان
چکیده
منابع مشابه
Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance
Obesity is a multifactor disease with a very complicated etiology. Genetic factors play an important role in the development of primary obesity. They may be responsible for up to 40% of causes leading to obesity. There are a great number of genes affecting food intake and energy expenditure. Serious consequences accompanying obesity, e.g., type 2 diabetes and lipid abnormalities may be caused b...
متن کاملInfluence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children
BACKGROUND Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C), but the results are equivocal. AIM This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children. SUBJECTS AN...
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متن کاملThe brain needs interleukin-6 (IL-6) to maintain a "healthy" energy balance. Focus on "IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons".
LARSEN AND COLLEAGUES’ (13) recent paper provides an important piece of evidence that leptin sensitivity is under dynamic control and that interleukin-6 (IL-6) is an important player in this control system. IL-6 may increase leptin sensitivity in the ventromedial hypothalamic nucleus (VMN) at least in part by modifying leptin receptor transport to the cell membrane in VMN neurons. This will hel...
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ژورنال
عنوان ژورنال: European Journal of Medical Research
سال: 2010
ISSN: 2047-783X
DOI: 10.1186/2047-783x-15-s2-123